High-Performance Cryo-Ring™ Sealing for Freeze-Dried Allergy Vaccines

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Overview

A pharmaceutical manufacturer faced critical sealing failures while producing freeze-dried allergy vaccines at –200°C. Traditional elastomers were becoming brittle and losing compression during long-duration static freezing. By switching to Vulcan Seals' FEP-encapsulated, spring-energised Cryo-Ring™ seals, the client eliminated cold-flow deformation and achieved consistent sealing integrity, ensuring the safety and quality of their vaccine production.

This case study showcases the capability of Cryo-Ring™ technology to deliver uncompromised reliability where standard materials fail.

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The Challenge

A pharmaceutical manufacturer in Hørsholm/Copenhagen producing freeze-dried allergy vaccines required a sealing solution capable of maintaining integrity at –200°C during long-duration static freezing cycles.​

Multiple elastomers (FPM, NBR, EPDM, VMQ) had been trialled but consistently failed due to brittleness, loss of elasticity, and inability to hold compression at cryogenic temperatures.​

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The Solution

Vulcan Seals supplied FEP-encapsulated spring-energised Cryo-Ring™ seals, incorporating:​

  • A fluoropolymer encapsulation suitable for temperatures down to –250°C for FEP and designed for cryogenic flexibility​
  • A 302 stainless steel spiral-wound energising spring that maintains sealing load even as materials contract at extreme temperatures​

Compared with solid polymer rings, Cryo-Ring™ seals:​

  • Hold consistent compression due to the internal spring​
  • Avoid cold-flow deformation, a known issue with solid polymer constructions ​
  • Provide reliable long-term sealing in fully static conditions at ultra-low temperatures​

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The Result

  • Significantly increased sealing reliability versus elastomer and solid-ring alternatives​
  • Stable sealing force maintained throughout full freezing cycles​
  • Enhanced assurance in product integrity for vaccine freeze-drying processes​
  • Performance fully aligned with Cryo-Ring™ temperature capability (–250°C) as detailed in technical literature​

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Contact the Vulcan Seals Experts

For industries and applications facing similar challenges with complex or critical equipment, Vulcan Seals offers a wealth of expertise in designing and manufacturing custom-engineered solutions that meet specific operational requirements.

Please use the form found on our Contact Us page and a Vulcan Seals expert will get back to you as soon as possible.

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